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Commun Biol. 2019 Sep 5;2:332. doi: 10.1038/s42003-019-0579-z. eCollection 2019.

Sex-specific Mendelian randomization study of genetically predicted insulin and cardiovascular events in the UK Biobank.

Author information

1
1School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
2
2City University of New York, School of Public Health and Health Policy, New York, NY USA.

Abstract

Insulin drives growth and reproduction which trade-off against longevity. Genetically predicted insulin, i.e., insulin proxied by genetic variants, is positively associated with ischemic heart disease, but sex differences are unclear, despite different disease rates and reproductive strategies by sex. We used Mendelian randomization in 392,010 white British from the UK Biobank to assess the sex-specific role of genetically predicted insulin in myocardial infarction (MI) (14,442 cases, 77% men), angina (21,939 cases, 65% men) and heart failure (5537 cases, 71% men). Genetically predicted insulin was associated with MI (odds ratio (OR) 4.27 per pmol/L higher insulin, 95% confidence interval (CI) 1.60 to 11.3) and angina (OR 2.93, 1.27 to 6.73) in men, but not women (MI OR 0.80, 95% CI 0.23 to 2.84, angina OR 1.10, 95% CI 0.38 to 3.18). Patterns were similar for insulin resistance and heart failure. Mitigating the effects of insulin might address sexual disparities in health.

KEYWORDS:

Genetic association study; Risk factors; Statistical methods

Conflict of interest statement

Competing interestsThe authors declare no competing interests.

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