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Ann Clin Transl Neurol. 2019 Sep 10. doi: 10.1002/acn3.50877. [Epub ahead of print]

11 C-PK11195 PET imaging and white matter changes in Parkinson's disease dementia.

Author information

1
Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom.
2
Department of Clinical Neurosciences, Geneva University Hospitals, Geneva, Switzerland.
3
Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.

Abstract

There is evidence of increased microglial activation in Parkinson's disease (PD) as shown by in vivo PET ligand such as 11 C-PK11195. In addition, diffusion tensor imaging (DTI) imaging reveals widespread changes in PD, especially when the associated dementia develops. In the present case series, we studied five subjects with Parkinson's disease dementia (PDD). Our findings suggest that while DTI metrics mirror cognitive severity, higher 11 C-PK11195 binding seems to be associated with a relative preservation of both white matter tracts and cognition. Longitudinal studies are warranted to tackle the complex relationship between microglial activation and structural abnormalities in neurodegenerative conditions.

PMID:
31507085
DOI:
10.1002/acn3.50877
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