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Qual Life Res. 2019 Sep 10. doi: 10.1007/s11136-019-02289-4. [Epub ahead of print]

Psychometric properties of the PROMIS® Fatigue Short Form 7a among adults with myalgic encephalomyelitis/chronic fatigue syndrome.

Author information

1
Department of Psychology, University of Rhode Island, 142 Flagg Road, Kingston, RI, 02881, USA. myang@uri.edu.
2
American Institutes for Research, Chapel Hill, NC, USA. myang@uri.edu.
3
American Institutes for Research, Chapel Hill, NC, USA.
4
Centers for Disease Control and Prevention, Atlanta, GA, USA.

Abstract

PURPOSE:

To evaluate the psychometric properties of the Patient-Reported Outcome Measurement Information System® Fatigue Short Form 7a (PROMIS F-SF) among people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

METHODS:

Analyses were conducted using data from the Multi-Site Clinical Assessment of ME/CFS study, which recruited participants from seven ME/CFS specialty clinics across the US. Baseline and follow-up data from ME/CFS participants and healthy controls were used. Ceiling/Floor effects, internal consistency reliability, differential item functioning (DIF), known-groups validity, and responsiveness were examined.

RESULTS:

The final sample comprised 549 ME/CFS participants at baseline, 386 of whom also had follow-up. At baseline, the sample mean of PROMIS F-SF T-score was 68.6 (US general population mean T-score of 50 and standard deviation of 10). The PROMIS F-SF demonstrated good internal consistency reliability (Cronbach's α = 0.84) and minimal floor/ceiling effects. No DIF was detected by age or sex for any item. This instrument also showed good known-groups validity with medium-to-large effect sizes (η2 = 0.08-0.69), with a monotonic increase of the fatigue T-score across ME/CFS participant groups with low, medium, and high functional impairment as measured by three different variables (p < 0.01), and with significantly higher fatigue T-scores among ME/CFS participants than healthy controls (p < 0.0001). Acceptable responsiveness was found with small-to-medium effect sizes (Guyatt's Responsiveness Statistic = 0.28-0.54).

CONCLUSIONS:

Study findings support the reliability and validity of PROMIS F-SF as a measure of fatigue for ME/CFS and lend support to the drug development tool submission for qualifying this measure to evaluate therapeutic effect in ME/CFS clinical trials.

KEYWORDS:

Ceiling/floor effects; Differential item functioning; Fatigue; Internal consistency reliability; Known-groups validity; Myalgic encephalomyelitis/chronic fatigue syndrome; Responsiveness

PMID:
31506915
DOI:
10.1007/s11136-019-02289-4

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