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Biochem Soc Trans. 2019 Sep 10. pii: BST20190252. doi: 10.1042/BST20190252. [Epub ahead of print]

Reshaping cAMP nanodomains through targeted disruption of compartmentalised phosphodiesterase signalosomes.

Author information

1
Institute of Cardiovascular and Medical Science, University of Glasgow, Glasgow G128QQ, U.K.
2
Institute of Cardiovascular and Medical Science, University of Glasgow, Glasgow G128QQ, U.K. George.Baillie@glasgow.ac.uk.

Abstract

Spatio-temporal regulation of localised cAMP nanodomains is highly dependent upon the compartmentalised activity of phosphodiesterase (PDE) cyclic nucleotide degrading enzymes. Strategically positioned PDE-protein complexes are pivotal to the homeostatic control of cAMP-effector protein activity that in turn orchestrate a wide range of cellular signalling cascades in a variety of cells and tissue types. Unsurprisingly, dysregulated PDE activity is central to the pathophysiology of many diseases warranting the need for effective therapies that target PDEs selectively. This short review focuses on the importance of activating compartmentalised cAMP signalling by displacing the PDE component of signalling complexes using cell-permeable peptide disrupters.

KEYWORDS:

cAMP; cyclic nucleotide phosphodiesterases; peptide array; peptide disruptors

PMID:
31506329
DOI:
10.1042/BST20190252

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