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Acta Paediatr. 2019 Sep 10. doi: 10.1111/apa.15004. [Epub ahead of print]

Diffusion Tensor Imaging is associated with motor outcomes of very preterm born children at 11 years of age.

Author information

1
Department of Pediatric Neurology, University of Turku, Turku, Finland.
2
Department of Pediatric Neurology, Turku University Hospital, Turku, Finland.
3
Department of Medical Physics, Turku University Hospital, Turku, Finland.
4
Turku PET Centre, Turku University Hospital, Turku, Finland.
5
Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
6
Turku University Hospital, Clinical Research Centre, Turku, Finland.
7
Department of Radiology, University of Turku, Turku, Finland.
8
Department of Radiology, Turku University Hospital, Turku, Finland.
9
University of Helsinki and Helsinki University Hospital, Children's Hospital, and Pediatric Research Center, Helsinki, Finland.

Abstract

AIM:

Very preterm children born less than 32 weeks of gestation are at risk for motor difficulties such as cerebral palsy and developmental coordination disorder. This study explores the association between diffusion tensor imaging metrics at term and motor outcomes at 11 years of age.

METHODS:

A cohort of 37 very preterm infants (mean gestational age 29 4/7, SD 2 0/7) born in 2004-2006 in Turku University Hospital underwent diffusion tensor imaging at term. A region-of-interest analysis of fractional anisotropy and mean diffusivity was performed. Motor outcomes at 11 years of age were measured with the Movement Assessment Battery for Children - Second Edition.

RESULTS:

The diffusion metrics of the corpus callosum (genu p=0.005, splenium p=0.049), the left corona radiata (p=0.035) and the right optic radiation (p=0.017) were related to later motor performance. Mean diffusivity decreased and fractional anisotropy increased in proportion to the improving performance.

CONCLUSION:

The diffusion metrics of the genu and splenium of the corpus callosum, the left corona radiata and the right optic radiation at term were associated with motor skills at 11 years of age. Diffusion tensor imaging should be further studied as a potential tool in recognising children at risk for motor impairment.

KEYWORDS:

Developmental coordination disorder; Movement Assessment Battery for Children - Second Edition; diffusion tensor imaging; motor development; very preterm infants

PMID:
31505069
DOI:
10.1111/apa.15004

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