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Nutr Rev. 2019 Sep 4. pii: nuz050. doi: 10.1093/nutrit/nuz050. [Epub ahead of print]

Effects of soy isoflavones on cognitive function: a systematic review and meta-analysis of randomized controlled trials.

Author information

1
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
2
Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
3
Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
4
National Cerebral and Cardiovascular Center, Osaka, Japan.
5
Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
6
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Abstract

CONTEXT:

The results of preclinical and observational studies support the beneficial effect of soy isoflavones on cognition.

OBJECTIVE:

This review aimed to evaluate the effects of soy isoflavones on cognition in adults.

DATA SOURCES:

The PUBMED, EMBASE, Ovid Medline, Cochrane Library, and clinicaltrials.gov databases were searched.

STUDY SELECTION:

Two researchers independently screened 1955 records, using the PICOS criteria: participants were adults; intervention was dietary sources with soy isoflavones or isolated soy isoflavones; comparator was any comparator; outcome was cognitive function; study type was randomized controlled trials (RCTs). A third researcher was consulted to resolve any discrepancies. Sixteen RCTs were included and their quality assessed.

DATA EXTRACTION:

Information on study design, characteristics of participants, and outcomes was extracted. PRISMA guidelines were followed.

DATA ANALYSIS:

A random-effects meta-analysis was used to pool estimates across studies. In the 16 RCTs (1386 participants, mean age = 60 y), soy isoflavones were found to improve overall cognitive function (standardized mean difference [SMD], 0.19; 95% confidence interval [CI], 0.07-0.32) and memory (SMD, 0.15; 95%CI, 0.03-0.26).

CONCLUSION:

The results showed that soy isoflavones may improve cognitive function in adults.

SYSTEMATIC REVIEW REGISTRATION:

PROSPERO registration no. CRD42018082070.

KEYWORDS:

cognition; isoflavones; meta-analysis

PMID:
31504836
DOI:
10.1093/nutrit/nuz050

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