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Cereb Cortex. 2019 Sep 4. pii: bhz198. doi: 10.1093/cercor/bhz198. [Epub ahead of print]

Organization of Propagated Intrinsic Brain Activity in Individual Humans.

Author information

1
Department of Radiology, Washington University, St. Louis, MO 63110, USA.
2
Department of Psychiatry, Washington University, St. Louis, MO 63110, USA.
3
Department of Neurology, Washington University, St. Louis, MO 63110, USA.
4
Department of Pediatrics, Washington University, St. Louis, MO 63110, USA.
5
Department of Biomedical Engineering, Washington University, St. Louis, MO 63110, USA.
6
Department of Occupational Therapy, Washington University, St. Louis, MO 63110, USA.

Abstract

Spontaneous infra-slow (<0.1 Hz) fluctuations in functional magnetic resonance imaging (fMRI) signals are temporally correlated within large-scale functional brain networks, motivating their use for mapping systems-level brain organization. However, recent electrophysiological and hemodynamic evidence suggest state-dependent propagation of infra-slow fluctuations, implying a functional role for ongoing infra-slow activity. Crucially, the study of infra-slow temporal lag structure has thus far been limited to large groups, as analyzing propagation delays requires extensive data averaging to overcome sampling variability. Here, we use resting-state fMRI data from 11 extensively-sampled individuals to characterize lag structure at the individual level. In addition to stable individual-specific features, we find spatiotemporal topographies in each subject similar to the group average. Notably, we find a set of early regions that are common to all individuals, are preferentially positioned proximal to multiple functional networks, and overlap with brain regions known to respond to diverse behavioral tasks-altogether consistent with a hypothesized ability to broadly influence cortical excitability. Our findings suggest that, like correlation structure, temporal lag structure is a fundamental organizational property of resting-state infra-slow activity.

KEYWORDS:

functional connectivity; hubs; infra-slow; networks; resting-state fMRI

PMID:
31504262
DOI:
10.1093/cercor/bhz198

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