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Cancer Invest. 2019;37(8):393-414. doi: 10.1080/07357907.2019.1660887. Epub 2019 Sep 10.

Virotherapy: Current Trends and Future Prospects for Treatment of Colon and Rectal Malignancies.

Author information

1
Perdana University-Royal College of Surgeons in Ireland School of Medicine (PU-RCSI) , Serdang , Malaysia.
2
Department of Avian Disease Research and Diagnostics, Razi Vaccine and Serum Research Institute, Agricultural Research Education and Extension Organization (AREEO) , Karaj , Iran.
3
Health Sciences Division, Abu Dhabi Women's College, Higher Colleges of Technology , Abu Dhabi , United Arab Emirates.
4
Department of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, Universit Putra Malaysia , Serdang , Malaysia.
5
Institute of Bioscience, Universiti Putra Malaysia , Serdang , Malaysia.

Abstract

Colorectal cancer (CRC) is one of the most common malignancies. In recent decades, early diagnosis and conventional therapies have resulted in a significant reduction in mortality. However, late stage metastatic disease still has very limited effective treatment options. There is a growing interest in using viruses to help target therapies to tumour sites. In recent years the evolution of immunotherapy has emphasised the importance of directing the immune system to eliminate tumour cells; we aim to give a state-of-the-art over-view of the diverse viruses that have been investigated as potential oncolytic agents for the treatment of CRC.

KEYWORDS:

Recombinant oncolytic virus; apoptosis; colorectal cancer; virotherapy

PMID:
31502477
DOI:
10.1080/07357907.2019.1660887
[Indexed for MEDLINE]

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