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Mikrochim Acta. 2019 Aug 27;186(9):650. doi: 10.1007/s00604-019-3741-x.

Ambient temperature fabrication of a covalent organic framework from 1,3,5-triformylphloroglucinol and 1,4-phenylenediamine as a coating for use in open-tubular capillary electrochromatography of drugs and amino acids.

Author information

1
Department of Chemistry, Capital Normal University, Beijing, 100048, People's Republic of China.
2
Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Center for Disease Prevention and Control, Beijing, 100013, People's Republic of China.
3
Department of Chemistry, Capital Normal University, Beijing, 100048, People's Republic of China. xiangyh@cnu.edu.cn.
4
Department of Chemistry, Capital Normal University, Beijing, 100048, People's Republic of China. yensh@cnu.edu.cn.

Abstract

A covalent organic framework (COF) named TpPa-1 was designed and synthesized at ambient temperature by an ultrasound-assisted method from 1,3,5-triformylphloroglucinol (Tp) and 1,4-phenylenediamine (Pa-1). It was utilized as a stationary phase in open-tubular capillary electrochromatography (OT-CEC). The column was coated with TpPa-1 using a covalent bonding strategy. The coated capillary was characterized by morphology, crystallography, and mesoporous analysis to confirm the successful fabrication. The OT-CEC method was utilized for the analysis of tetracyclines, sulfonamides, cephalosporins and amino acids with high-resolution (Rs > 1.81) and good precision (RSD < 4.9%). It takes about 12 h from COF preparation to OT-CEC separation. Graphical abstract A covalent organic framework (COF) named TpPa-1 was synthesized at ambient temperature by an ultrasound-assisted method from 1,3,5-triformylphloroglucinol (Tp) and 1,4-phenylenediamine (Pa-1). COF-TpPa-1 modified capillary column was utilized for the analysis of tetracyclines, sulfonamides, cephalosporins and amino acids with high-resolution and good precision.

KEYWORDS:

Ambient temperature fabrication; Amino acids; Cephalosporins; Covalent bonding strategy; Covalent organic frameworks; Open-tubular capillary electrochromatography; Sulfonamides; Tetracyclines; TpPa-1

PMID:
31501947
DOI:
10.1007/s00604-019-3741-x

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