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J Am Acad Dermatol. 2019 Sep 6. pii: S0190-9622(19)32680-5. doi: 10.1016/j.jaad.2019.08.072. [Epub ahead of print]

Racial differences in dermatological conditions associated with Human Immunodeficiency Virus: a cross-sectional study of 4,679 patients in an urban tertiary care center.

Author information

1
Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD.
2
Center for Chronic Pruritus, Department of Dermatology, University of Münster, Münster, Germany.
3
Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD; Johns Hopkins Bloomberg School of Public Health, Baltimore, MD. Electronic address: skwatra1@jhmi.edu.

Abstract

BACKGROUND:

Due to reduced mortality, patients with HIV are living longer and presenting with chronic diseases. Little is known about racial differences in dermatologic conditions associated with HIV infection.

OBJECTIVE:

This study examines associated dermatologic conditions in a large population of HIV patients at a tertiary care center with a diverse patient population.

METHODS:

Cross-sectional study of patients with HIV seen between July 14, 2013 and July 14, 2018 in a tertiary health care system. The burden of HIV-related dermatologic conditions was collected using medical records. Patients with HIV were compared with controls of the same race and significance was assessed using chi-square testing. A Bonferroni correction was performed to control for multiple hypothesis testing.

RESULTS:

The study population (n=4,679) was 64.7% male and 69% African American, with 88.7% of patients on anti-retroviral therapy (ART). African American patients with HIV had a greater risk of oral hairy leukoplakia (OR 64.49), herpes zoster (OR 9.27), prurigo nodularis (OR 8.80), and squamous cell carcinoma (OR 5.72).

LIMITATIONS:

Our data describe patients seen by one health care system.

CONCLUSIONS:

African American patients with HIV may be at increased risk for pruritic disorders compared with race-matched controls as well as white patients with HIV.

KEYWORDS:

Antiretroviral Therapy; Human Immunodeficiency Virus; Kaposi’s Sarcoma; Oral Hairy Leukoplakia; Prurigo Nodularis; Pruritus

PMID:
31499147
DOI:
10.1016/j.jaad.2019.08.072

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