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Clin Transplant. 2019 Oct;33(10):e13706. doi: 10.1111/ctr.13706. Epub 2019 Oct 16.

Marijuana use should not preclude consideration for kidney transplantation.

Author information

1
Department of Pharmacy, Hennepin Healthcare, Minneapolis, MN, USA.
2
Department of Nephrology, Hennepin Healthcare, Minneapolis, MN, USA.
3
Department of Surgery, Hennepin Healthcare, Minneapolis, MN, USA.

Abstract

Transplant eligibility for tobacco and/or marijuana using candidates varies among transplant centers. This study compared the impact of marijuana use and tobacco use on kidney transplant recipient outcomes. Kidney transplant recipients at a single center from 2001 to 2015 were reviewed for outcomes of all-cause graft loss, infection, biopsy-proven acute rejection, and estimated glomerular filtration rate between four groups: marijuana-only users, marijuana and tobacco users, tobacco-only users, and nonusers. The cohort (N = 919) included 48 (5.2%) marijuana users, 45 (4.8%) marijuana and tobacco users, 136 (14.7%) tobacco users, and 75% nonusers. Smoking status was not significantly associated with acute rejection, estimated glomerular filtration rate or pneumonia within one-year post-transplant in an adjusted model. Compared to nonuse, marijuana and tobacco use and tobacco-only use was significantly associated with increased risk of graft loss (aHR 1.68, P = .034 and 1.52, P = .006, respectively). Patients with isolated marijuana use had similar overall graft survival compared to nonusers (aHR 1.00, P = .994). Marijuana use should not be an absolute contraindication to kidney transplant.

KEYWORDS:

alcoholism and substance abuse; graft survival; kidney (allograft) function/dysfunction

PMID:
31498490
DOI:
10.1111/ctr.13706

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