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J Alzheimers Dis. 2019 Sep 3. doi: 10.3233/JAD-190545. [Epub ahead of print]

Exosomal HSP70 for Monitoring of Frontotemporal Dementia and Alzheimer's Disease: Clinical and FDG-PET Correlation.

Author information

1
INSERM, UMR1231, Labex LipSTIC, Dijon, France.
2
Université de Bourgogne-Franche Comté, Dijon, France.
3
Department of Neurology and Laboratory of Neurobiology, Hospital Clinico San Carlos, Health Research Institute "San Carlos" (IdISCC), Universidad Complutense de Madrid. Madrid, Spain.
4
Cancer Centre Georges François Leclerc, Dijon, France.
5
Department of Nuclear Medicine. Hospital Clinico San Carlos, Health Research Institute "San Carlos" (IdISCC), Universidad Complutense de Madrid, Madrid, Spain.

Abstract

We aimed to study the expression of circulating heat-shock protein HSP70 and exosomes in plasma of a cohort of patients with Alzheimer's disease (AD) and frontotemporal dementia (FTD) at different stages. We performed correlations with clinical scales and FDG-PET. HSP70 levels were higher within exosomes than free in plasma. Moderate correlations were found between exosomal HSP70 and CDR, FTLD-CDR, and extension of hypometabolism. Our results suggest modifications in the level of exosomal HSP70 during the course of neurodegeneration, regardless of AD or FTD, and therefore HSP70 could have a potential role in the follow-up of these disorders.

KEYWORDS:

Alzheimer’s disease; PET; biomarkers; exosomes; frontotemporal dementia

PMID:
31498123
DOI:
10.3233/JAD-190545

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