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Mult Scler. 2019 Sep 9:1352458519872465. doi: 10.1177/1352458519872465. [Epub ahead of print]

Day-to-day reliability, agreement and discriminative validity of measuring walking-related performance fatigability in persons with multiple sclerosis.

Author information

1
REVAL Rehabilitation Research Center, BIOMED, Faculty of Rehabilitation Sciences, Hasselt University, Diepenbeek, Belgium.
2
Ter Heide, Genk, Belgium/Hasselt University, Diepenbeek, Belgium.
3
Section of Sport Science, Department of Public Health, Aarhus University, Aarhus, Denmark.

Abstract

BACKGROUND:

Day-to-day reliability and cut-off values to detect abnormal walking fatigability (WF) remain to be investigated in persons with multiple sclerosis (pwMS).

METHODS:

In all, 49 pwMS (mean Expanded Disability Status Scale (EDSS) ± standard deviation (SD): 3.3 ± 1.9) and 28 matched healthy controls (HC) performed the six-minute walking test (6MWT) on two different days to determine day-to-day reliability (intraclass correlation coefficient (ICC)) and limits of agreement (LOA) for five different equations of WF.

OBJECTIVE:

To examine day-to-day reliability, agreement and discriminative validity for measuring WF.

RESULTS AND CONCLUSION:

WF expressed as the ratio between the first and sixth minute had the best day-to-day reliability (ICC's range of 0.76-0.95 and 0.60-0.86, respectively) in both pwMS and HC, while LOA were 15% and 7%, respectively. Ecological validity and clinical importance should be further investigated.

KEYWORDS:

Reliability; assessment; fatigability; multiple sclerosis; walking

PMID:
31496362
DOI:
10.1177/1352458519872465

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