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Trends Neurosci. 2019 Sep 5. pii: S0166-2236(19)30159-6. doi: 10.1016/j.tins.2019.08.009. [Epub ahead of print]

Microglia in Memory Decline from Zika Virus and West Nile Virus Infection.

Author information

1
Center for Innate Immunity and Immune Disease, University of Washington, Seattle, WA, USA; Department of Immunology, University of Washington, Seattle, WA, USA; Washington National Primate Research Center, Seattle, WA, USA.
2
Center for Innate Immunity and Immune Disease, University of Washington, Seattle, WA, USA; Department of Immunology, University of Washington, Seattle, WA, USA; Washington National Primate Research Center, Seattle, WA, USA; Department of Global Health, University of Washington, Seattle, WA, USA. Electronic address: mgale@uw.edu.

Abstract

Neurotropic viral infection can result in complications underscored by persistent T cell presence in the brain linked with cognitive decline. A recent study by Garber et al. showed that sustained T cell production of interferon (IFN)-γ mediating microglia activation triggers cognitive decline during recovery from Zika virus (ZIKV) or West Nile virus (WNV) infection.

KEYWORDS:

flavivirus; memory; microglia

PMID:
31495452
DOI:
10.1016/j.tins.2019.08.009

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