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Epilepsy Behav. 2019 Sep 4:106488. doi: 10.1016/j.yebeh.2019.106488. [Epub ahead of print]

Gene networks and microRNAs: Promises and challenges for treating epilepsies and their comorbidities.

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Section of Pharmacology, Department of Medical Sciences, University of Ferrara, Italy.
Section of Pharmacology, Department of Medical Sciences, University of Ferrara, Italy; School of Medicine, University Vita-Salute San Raffaele, Milan, Italy. Electronic address:


Neurobiology research has used an essentially reductionist approach for many years, dissecting out the brain in more simple elements. Recent technical advances, like systems biology, have made now possible to embrace a more holistic vision and try to tackle the complexity of the system. In this short review, we describe how these approaches, in particular analyses or gene networks and of microRNAs, may be useful for epilepsy research. We will describe and discuss recent studies that illustrate how these research approaches can lead to the identification of therapeutic targets and pharmacological strategies to prevent or treat some forms of epilepsy. We aim to show that studying epilepsy and its comorbidities within a complex system framework is a promising integration to the traditional reductionist approaches, and that it will become more and more important in the future for developing new therapies. This article is part of the Special Issue "NEWroscience 2018."


Epileptogenesis; Seizures; Sestrin3; Systems biology; miRNA

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