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Trends Endocrinol Metab. 2019 Oct;30(10):735-744. doi: 10.1016/j.tem.2019.07.021. Epub 2019 Sep 5.

Maternal Microbiome and Metabolic Health Program Microbiome Development and Health of the Offspring.

Author information

1
Institute of Agrochemistry and Food Technology (IATA-CSIC), National Research Council, Valencia, Spain; Center for Microbial Ecology and Technology (CMET), Ghent University, Ghent, Belgium.
2
Azrieli Faculty of Medicine, Bar Ilan University, Safed, Israel.
3
Institute of Agrochemistry and Food Technology (IATA-CSIC), National Research Council, Valencia, Spain. Electronic address: mcolam@iata.csic.es.

Abstract

Maternal nutritional, metabolic, and physiological states, as well as exposure to various environmental factors during conception, gestation, and lactation, have a fundamental role in the health programming of the offspring. Therefore, alterations affecting the maternal microbiota might indirectly influence fetal development. In addition, such alterations could be transmitted to the progeny at different stages of infant development (e.g., preconception, prenatal, or postnatal), thereby favoring the development of an altered microbiota in the neonate. Microbial changes of this kind have been linked to an increased risk of non-communicable diseases (NCDs), including obesity and metabolic syndrome, allergy-related problems, and diabetes. In this review, we summarize the relevance of the maternal microbiota to fetal-neonatal health programming, with a focus on maternal nutritional and metabolic states.

KEYWORDS:

C-section; antibiotic; diabetes; lactation; microbiota; neonatal health; nutrition; obesity

PMID:
31493988
DOI:
10.1016/j.tem.2019.07.021

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