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J Nanosci Nanotechnol. 2020 Apr 1;20(4):2104-2113. doi: 10.1166/jnn.2020.17360.

Graphene Oxide Covalently Grafted Fe₂B@SiO₂ Nanoparticles for Epirubicin Loading and Releasing.

Author information

1
School of Chemistry and Molecular Engineering, East China University of Science & Technology, Shanghai 200237, China.
2
State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, Jilin University, Changchun 130012, China.
3
Analysis Test Center, Yangzhou University, Yangzhou 225009, China.
4
Department of Materials Science and Engineering, University of Delaware, DE 19716, USA.

Abstract

In this work, stable superparamagnetic core-shell Fe₂B@SiO₂ nanoparticles were prepared by "one pot" chemical reduction of ferric ion salts with NaBH₄ and silica shell coating in the presence of citric acid stabilizer. The X-ray (XRD) and selection of electron diffraction (SAED) revealed that Fe₂B@SiO₂ nanoparticles were chiefly composed of silica shell and Fe₂B with a small amount of α-Fe. Then, graphene oxide (GO) was assembled onto core-shell Fe₂B@SiO₂ nanoparticles for Epirubicin (EPI) loading and releasing, and the adsorption isotherm of EPI on Fe₂B@SiO₂@GO was analyzed. The results showed, the adsorption process includes two steps, due to the π-π stacking effect of EPI on the Fe₂B@SiO₂@GO. The EPI loading efficiency of the magnetic nanoparticles was as high as 90%, while the EPI-loaded core-shell Fe₂B@SiO₂ nanoparticles showed an obvious pH controlled drug release behavior, and showed lower cumulative release rate when pH is 7.4 than that when pH is 5.7. The prepared nanoparticles demonstrated potential application in killing tumor cells while minimizing the toxicity to normal tissues.

PMID:
31492218
DOI:
10.1166/jnn.2020.17360

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