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Int J Mol Sci. 2019 Sep 5;20(18). pii: E4364. doi: 10.3390/ijms20184364.

Biomaterial-Based Approaches for Regeneration of Periodontal Ligament and Cementum Using 3D Platforms.

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Department of Dental Biomaterials, School of Dentistry, Kyungpook National University, Daegu 41940, Korea.
Institute for Biomaterials Research and Development, Kyungpook National University, Daegu 41940, Korea.


Currently, various tissue engineering strategies have been developed for multiple tissue regeneration and integrative structure formations as well as single tissue formation in musculoskeletal complexes. In particular, the regeneration of periodontal tissues or tooth-supportive structures is still challenging to spatiotemporally compartmentalize PCL (poly-ε-caprolactone)-cementum constructs with micron-scaled interfaces, integrative tissue (or cementum) formations with optimal dimensions along the tooth-root surfaces, and specific orientations of engineered periodontal ligaments (PDLs). Here, we discuss current advanced approaches to spatiotemporally control PDL orientations with specific angulations and to regenerate cementum layers on the tooth-root surfaces with Sharpey's fiber anchorages for state-of-the-art periodontal tissue engineering.


biomaterials; cementum; periodontal ligament; periodontal tissues; regenerative medicine; tissue engineering

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