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Nutrients. 2019 Sep 5;11(9). pii: E2109. doi: 10.3390/nu11092109.

Low Serum Vitamin D Concentrations Are Associated with Insulin Resistance in Mexican Children and Adolescents.

Author information

1
Nutrition and Health Research Center, National Institute of Public Health, Cuernavaca, Morelos 62100, Mexico. edgar.denova@insp.mx.
2
CONACYT-Center for Population Health Research, National Institute of Public Health, Cuernavaca, Morelos 62100, Mexico. pmz.aguirre@gmail.com.
3
Clinical Epidemiology Research Unit, Hospital Infantil de México Federico Gómez, Mexico City 06720, Mexico. desiree_15@hotmail.com.
4
Nutrition and Health Research Center, National Institute of Public Health, Cuernavaca, Morelos 62100, Mexico. mario.flores@insp.mx.
5
Nephrology and Bone Mineral Metabolism Research Unit, Hospital Infantil de México Federico Gómez, Mexico City 06720, Mexico. medeiro.mara@gmail.com.
6
School of Medicine, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico. nataliatamborrel@gmail.com.
7
Clinical Epidemiology Research Unit, Hospital Infantil de México Federico Gómez, Mexico City 06720, Mexico. osteoclark@gmail.com.
8
School of Medicine, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico. osteoclark@gmail.com.

Abstract

Previous studies in the Mexican adult population have suggested a relationship between low levels of serum concentrations of serum vitamin D with impaired glucose tolerance, metabolic syndrome, and diabetes, regardless of the presence of obesity. The aim of this study is to investigate the relationship between serum vitamin D levels and the factors linked to insulin resistance. A total of 533 children and adolescents from the "Reference Values of Body Composition in the Pediatric Population of Mexico City" study are assessed. Body composition, dietary, and lifestyle data are obtained. Serum vitamin D, insulin, and glucose are also measured. Associations are tested using multiple linear and logistic regression models. Approximately 90% of children and adolescents in this study have sub-optimal vitamin D levels (<30 ng/mL). An inverse relationship between insulin resistance and serum vitamin D is observed (OR (odds ratios) = 2.9; 95% CI (95% confidence intervals): 1.1, 7.2; p-trend 0.03). Low serum vitamin D levels are associated with insulin resistance in the pediatric population. The present study provides additional evidence for the role of vitamin D in insulin resistance. Our findings suggest the supplementation of vitamin D may be helpful in preventing insulin resistance and subsequent diabetes.

KEYWORDS:

adolescents; children; diabetes; insulin resistance; vitamin D

PMID:
31491877
DOI:
10.3390/nu11092109
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