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Cell Calcium. 2019 Nov;83:102075. doi: 10.1016/j.ceca.2019.102075. Epub 2019 Aug 28.

Recent progress in structural studies on canonical TRP ion channels.

Author information

1
State Key Laboratory of Membrane Biology, Institute of Molecular Medicine, Peking University, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Beijing 100871, China.
2
State Key Laboratory of Membrane Biology, Institute of Molecular Medicine, Peking University, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Beijing 100871, China; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China; Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China. Electronic address: chenlei2016@pku.edu.cn.

Abstract

Canonical TRP channels (TRPC) are non-selective cation channels that are involved in various important physiological processes. Currently, the structures of different TRPC ion channel family members are resolved by cryo-EM at resolutions ranging from 2.8 Å to 5.8 Å. These structures reveal the conserved architecture of TRPC ion channels as well as the specific features of each channel subtype. This review focuses on the structural differences in the extracellular portions, transmembrane domains and the cytoplasmic domains of TRPC channels.

KEYWORDS:

BTDM; Ion channel; TRP; TRPC

PMID:
31491644
DOI:
10.1016/j.ceca.2019.102075

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