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Cell. 2019 Sep 5;178(6):1284-1286. doi: 10.1016/j.cell.2019.08.024.

The Face of Chromatin Variants.

Author information

1
Centre for Chromosome Biology, Biochemistry, School of Natural Sciences, National University of Ireland Galway, Ireland.
2
Centre for Gene Regulation and Expression, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland. Electronic address: t.a.owenhughes@dundee.ac.uk.

Abstract

A developmental program affecting human face shape is shown by Greenberg et al. (2019) to hinge on the ability to distinguish a single methyl group between two histone variant isoforms and the action of the chromatin-remodeling enzyme SRCAP. This challenges researchers to link atomic structure to a morphological defect.

PMID:
31491382
DOI:
10.1016/j.cell.2019.08.024

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