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J Agric Food Chem. 2019 Oct 2;67(39):10977-10983. doi: 10.1021/acs.jafc.9b02806. Epub 2019 Sep 19.

Simultaneous Determination of Five Diamide Insecticides in Food Matrices Using Carbon Nanotube Multiplug Filtration Cleanup and Ultrahigh-Performance Liquid Chromatography-Tandem Mass Spectrometry.

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Laboratory of Quality & Safety Risk Assessment for Ginseng and Antler Products , Jilin Agricultural University , Changchun , Jilin 130118 , China.
School of Plant Protection , Jilin Agricultural University , Changchun , Jilin 130118 , China.


In this study, an analytical method was developed and validated for simultaneous determination of five diamide insecticides (chlorantraniliprole, cyantraniliprole, flubendiamide, cyclaniliprole, and tetrachlorantraniliprole) in food matrices. Determination of the latter two diamide compounds is first reported. Samples were cleaned up by multiplug filters containing carbon nanotubes (CNT) or hydrophilic-lipophilic balanced copolymers (HLB) and classic dispersive solid phase extraction (d-SPE) procedures, respectively. The CNT multiplug filter performed the best in terms of process rapidity and cleanup efficiency; thus, it was finally chosen for sample cleanup. Instrumental analysis was completed in 5 min using ultrahigh-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). Mean recoveries of the five diamides ranged from 84.3 to 110.0%, with intraday and interday relative standard deviations (RSD) of less than 13.5%. Limits of quantitation (LOQ) of all analytes ranged from 0.005 to 0.01 mg kg-1 in different matrices. The results indicate this method is reliable for monitoring the five diamide insecticides in various foods.


UHPLC-MS/MS; diamide insecticide; food; multiplug filtration


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