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J Agric Food Chem. 2019 Sep 25;67(38):10553-10562. doi: 10.1021/acs.jafc.9b03602. Epub 2019 Sep 16.

Chlorpyrifos Induces Metabolic Disruption by Altering Levels of Reproductive Hormones.

Li J1, Ren F1,2,3, Li Y1, Luo J4,3, Pang G1.

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Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering , China Agricultural University , Beijing 100083 , China.
Key Laboratory of Functional Dairy, Co-constructed by Ministry of Education and Beijing Government , China Agricultural University , Beijing 100083 , China.
Beijing Laboratory of Food Quality and Safety , Beijing University of Agriculture , Beijing 100096 , China.
College of Food Science and Technology , Hunan Agricultural University , Changsha 410114 , China.


Chlorpyrifos (CPF) is a widely used organophosphorus pesticide and detected frequently in fruits, vegetables, as well as in urine and blood in humans. Studies have suggested that CPF can induce metabolic disruption, such as type-2 diabetes mellitus and changed body weight. The main mechanisms are based on oxidative damage, fatty-acid synthesis, and lipid peroxidation. Studies have also shown that CPF can change reproductive hormone (RH) levels. CPF might result in metabolic disorders through altered RH levels. Here, we review the studies showing that CFP causes metabolic disruption. Then, we present the studies showing that CFP changes RH levels. Finally, we discuss a potential pathway of how CPF elicits metabolic disruption.


T2DM; chlorpyrifos; gonadotropins; obesity; sex hormones

[Indexed for MEDLINE]

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