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J Natl Compr Canc Netw. 2019 Sep 1;17(9):1109-1133. doi: 10.6004/jnccn.2019.0043.

Small Bowel Adenocarcinoma, Version 1.2020, NCCN Clinical Practice Guidelines in Oncology.

Author information

1
1Robert H. Lurie Comprehensive Cancer Center of Northwestern University.
2
2UCSF Helen Diller Family Comprehensive Cancer Center.
3
3University of Michigan Rogel Cancer Center.
4
4City of Hope National Medical Center.
5
5Vanderbilt-Ingram Cancer Center.
6
6Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance.
7
7Fox Chase Cancer Center.
8
8University of Wisconsin Carbone Cancer Center.
9
9Huntsman Cancer Institute at the University of Utah.
10
10Fred & Pamela Buffett Cancer Center.
11
11Moffitt Cancer Center.
12
12Mayo Clinic Cancer Center.
13
13Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine.
14
14O'Neal Comprehensive Cancer Center at UAB.
15
15Stanford Cancer Institute.
16
16Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute.
17
17University of Colorado Cancer Center.
18
18Dana-Farber/Brigham and Women's Cancer Center.
19
19The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute.
20
20Roswell Park Comprehensive Cancer Center.
21
21The University of Texas MD Anderson Cancer Center.
22
22Massachusetts General Hospital Cancer Center.
23
23UC San Diego Moores Cancer Center.
24
24Memorial Sloan Kettering Cancer Center.
25
25Abramson Cancer Center at the University of Pennsylvania.
26
26The University of Tennessee Health Science Center.
27
27The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins.
28
28Duke Cancer Institute; and.
29
29National Comprehensive Cancer Network.

Abstract

Small bowel adenocarcinoma (SBA) is a rare malignancy of the gastrointestinal tract that has increased in incidence across recent years. Often diagnosed at an advanced stage, outcomes for SBA are worse on average than for other related malignancies, including colorectal cancer. Due to the rarity of this disease, few studies have been done to direct optimal treatment, although recent data have shown that SBA responds to treatment differently than colorectal cancer, necessitating a separate approach to treatment. The NCCN Guidelines for Small Bowel Adenocarcinoma were created to establish an evidence-based standard of care for patients with SBA. These guidelines provide recommendations on the workup of suspected SBA, primary treatment options, adjuvant treatment, surveillance, and systemic therapy for metastatic disease. Additionally, principles of imaging and endoscopy, pathologic review, surgery, radiation therapy, and survivorship are described.

PMID:
31487687
DOI:
10.6004/jnccn.2019.0043

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