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Bioinformation. 2019 Jul 31;15(7):506-512. doi: 10.6026/97320630015506. eCollection 2019.

Inhibition studies of HBV DNA polymerase using seed extracts of Pongamia pinnata.

Author information

1
Centre for Drug Discovery and Development, Col. Dr.Jeppiaar Research Park, Sathyabama Institute of Science and Technology, Chennai.
2
Department of Biochemistry, Saveetha Dental College and Hospital, Chennai 77.
3
Department of Bioinformatics, Science Campus, Alagappa University, Karaikudi.

Abstract

Several antiviral compounds for HBV have been identified from traditionally used medicinal plants. We have earlier described the immune modulation properties of P. pinnata, a traditionally used Indian medicinal plant. Therefore, it is of interest to explore the anti-Hepatitis B virus activity of P. pinnata extracts by in-vitro screening assays. This study clearly demonstrated that the 5mg/ml concentration of the aqueous extract significantly inhibited the virus binding. Further, the spectral study was carried out for finding active compounds. The active chalcone derivatives namely, glabaarachalcone, and isopongachromene were isolated from P. pinnata aqueous seed extracts by standard spectral procedures. Virtual screening data shows that glabaarachalcone, and isopongachromene bound with HBV DNA polymerase protein target.

KEYWORDS:

DNA; HBV; Pongamia pinnata; polymerase

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