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BMC Pediatr. 2019 Sep 4;19(1):312. doi: 10.1186/s12887-019-1659-4.

Maternal age at menarche and offspring body mass index in childhood.

Author information

1
MOE-Shanghai Key Laboratory of Children's Environmental Health, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kong Jiang Road, Shanghai, 200092, China.
2
Child Health Advocacy Institute, Shanghai Children's Medical Center Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China.
3
School of public health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
4
Department of Developmental and Behavioral Pediatrics, Shanghai Children's Medical Center Affiliated to Shanghai Jiao Tong University School of Medicine, 1678 Dong Fang Road, Shanghai, 200127, China. fanjiang@shsmu.edu.cn.
5
MOE-Shanghai Key Laboratory of Children's Environmental Health, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kong Jiang Road, Shanghai, 200092, China. junjimzhang@sina.com.

Abstract

BACKGROUND:

Earlier age of menarche has been associated with an increased risk of chronic diseases during adulthood, but whether early menarche has intergenerational effect is not clear.

METHODS:

In this population-based cross-sectional study, we recruited children from 26 primary schools using cluster random probability sampling in Shanghai, China, in 2014. We used multiple linear regression models to estimate the adjusted associations of maternal age of menarche (MAM) with offspring body mass index (BMI). We also used the mediation analysis to examine the contribution of maternal BMI and gestational diabetes to offspring BMI.

RESULTS:

A total of 17,571 children aged 6-13 years were enrolled, of whom 16,373 had their weight and height measured. Earlier MAM was associated with higher child BMI in boys (- 0.05 z-score per year older MAM, 95% CI - 0.08 to - 0.02) and in girls (- 0.05 z-score per year older MAM, 95% CI - 0.07 to - 0.02). Maternal BMI positively mediated the association of MAM with offspring BMI in both sexes, with mediation effects of 37.7 and 19.4% for boys and girls, respectively.

CONCLUSION:

Early maternal menarche was associated with greater offspring BMI. This study provides evidence for the intergenerational effect in the development of BMI in offspring.

KEYWORDS:

Body mass index; Early menarche; Intergenerational study

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