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Endocr Connect. 2019 Sep 1;8(9):1240-1249. doi: 10.1530/EC-19-0325.

Adherence and long-term outcomes of growth hormone therapy with easypod™ in pediatric subjects: Spanish ECOS study.

Author information

Pediatric Endocrinology Unit, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Hospital Universitario Araba, Araba/Alava, Spain.
Hospital Universitario Príncipe de Asturias, Oviedo, Spain.
Centro Nuevas Tecnologias, Sevilla, Spain.
Hospital Vall d'Hebrón, Barcelona, Spain.
Complejo Hospitalario de Navarra, Pamplona, Spain.
Corporació Sanitària Parc Taulí, Sabadell, Barcelona, Spain.
Merck S.L.U., Madrid, Spain.



Non-adherence to r-hGH treatments occurs in a variable percentage of subjects. One problem found when evaluating adherence is the great variability in methods of detection and definitions utilized in studies. This study assessed the level of adherence in subjects receiving r-hGH with the easypod™ electronic device.


National, multicenter, prospective and observational study involving 238 subjects (144 with GH deficiency (GHD), and 86 with small for gestational age (SGA), 8 with Turner Syndrome), who received r-hGH with easypod™ for at least 3 months before inclusion. The follow-up period was 4 years.


Overall adherence was 94.5%; 97.5% after 6 months, 95.3% after 1 year, 93.7% after 2, 94.4% after 3 and 95.5% after 4 years of treatment. No differences in adherence were observed between prepubertal and pubertal groups and GHD and SGA groups. Change in height after 1 and 2 years, change in height SDS after 1 and 2 years, HV after 1 year, HV SDS after at 1 and 4 years, change in BMI after 1 year and change in BMI SDS at 1 and 2 years showed significant correlation with adherence. No significant differences in adherence according to IGF-I levels were found in follow-up visits or between groups.


The easypod™ electronic device, apart from being a precise and objective measure of adherence to r-hGH treatment, allows high compliance rates to be achieved over long periods of time. Adherence significantly impacts growth outcomes associated with r-hGH treatment.


adherence; e-health; easypod; electronic device; long-term; outcomes; pediatrics; r-hGH

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