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Cancer Immunol Immunother. 2019 Sep 3. doi: 10.1007/s00262-019-02383-z. [Epub ahead of print]

A phase II study of the L19IL2 immunocytokine in combination with dacarbazine in advanced metastatic melanoma patients.

Author information

1
Department of Dermatology, University Medical Center, Tübingen, Germany.
2
Division of Thoracic Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy.
3
Istituto Nazionale Tumori, IRCCS Fondazione Pascale, Naples, Italy.
4
Ospedali Riuniti Ancona, Ancona, Italy.
5
Università di Modena e Reggio Emilia, Modena, Italy.
6
Medical University of Graz, Graz, Austria.
7
Translational Skin Cancer Research, Deutsches Konsortium für Translationale Krebsforschung (DKTK) Partner Site Essen, Essen, Germany.
8
Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.
9
University Hospital Schleswig-Holstein (UKSK), Campus Kiel, Kiel, Germany.
10
Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.
11
Azienda Ospedaliero-Universitaria Senese, Siena, Italy.
12
University Hospital Zurich and University Zurich, Zurich, Switzerland.
13
Charité, Berlin, Germany.
14
Dermatologikum Berlin, Berlin, Germany.
15
Philochem AG, Libernstrasse 3, 8112, Otelfingen, Switzerland. giuliano.elia@philogen.com.
16
Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zurich, Building HCI G396.4, Wolfgang-Pauli-Strasse 10, 8093, Zurich, Switzerland. dario.neri@pharma.ethz.ch.
17
Department of Dermatology, University Medical Center, Tübingen, Germany. claus.garbe@med.uni-tuebingen.de.
18
Sektion Dermatologische Onkologie, Universität Tübingen Hautklinik, Liebermeisterstraße 25, 72076, Tübingen, Germany. claus.garbe@med.uni-tuebingen.de.

Abstract

Engineered cytokine products represent promising agents for the treatment of immunogenic tumors, such as malignant melanoma, in addition to immune checkpoint inhibitors. Here we describe the results of a controlled, randomized phase II clinical trial, aimed at assessing the therapeutic potential of L19IL2, a fully human fusion protein consisting of the L19 antibody specific to the alternatively spliced extra-domain B of fibronectin, fused to human interleukin-2 in advanced metastatic melanoma. In one arm, patients received dacarbazine (DTIC; 1000 mg/m2 of body surface on day 1 of 21-day cycles) as single agent, while in two other arms L19IL2 (22.5 million international units of IL2 equivalents) was added, based on two different schedules of administration. In total, 69 patients with stage IV melanoma were enrolled (24 in the dacarbazine arm, 23 and 22 in the other combination arms, respectively) and 67 received treatment. Analyses of efficacy results show a statistically significant benefit in terms of overall response rate and median progression-free survival for patients receiving L19IL2 in combination with DTIC, compared to DTIC as single agent. In light of these results, further clinical investigations with L19IL2 (alone or in combination with other agents) are warranted.

KEYWORDS:

Dacarbazine; Immunocytokine; L19IL2; Phase II study; Stage IV melanoma

PMID:
31482307
DOI:
10.1007/s00262-019-02383-z

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