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Nat Cell Biol. 2019 Sep;21(9):1060-1067. doi: 10.1038/s41556-019-0384-4. Epub 2019 Sep 2.

The cell cycle in stem cell proliferation, pluripotency and differentiation.

Author information

1
College of Life and Health Sciences, Key Laboratory of Data Analytics and Optimization for Smart Industry (Ministry of Education), Northeastern University, Shenyang, Liaoning, China.
2
Department of Cancer Biology, Dana-Farber Cancer Institute and Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
3
Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA, USA.
4
Department of Cancer Biology, Dana-Farber Cancer Institute and Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA. Peter_Sicinski@dfci.harvard.edu.

Abstract

Cyclins, cyclin-dependent kinases and other components of the core cell cycle machinery drive cell division. Growing evidence indicates that this machinery operates in a distinct fashion in some mammalian stem cell types, such as pluripotent embryonic stem cells. In this Review, we discuss our current knowledge of how cell cycle proteins mechanistically link cell proliferation, pluripotency and cell fate specification. We focus on embryonic stem cells, induced pluripotent stem cells and embryonic neural stem/progenitor cells.

PMID:
31481793
DOI:
10.1038/s41556-019-0384-4

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