Format

Send to

Choose Destination
Early Hum Dev. 2019 Nov;138:104854. doi: 10.1016/j.earlhumdev.2019.104854. Epub 2019 Aug 31.

The role of the preterm intestinal microbiome in sepsis and necrotising enterocolitis.

Author information

1
Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.
2
Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK. Electronic address: Christopher.Stewart@newcastle.ac.uk.

Abstract

Late-onset sepsis (LOS) and necrotising enterocolitis (NEC) account for the highest number of deaths in premature infants and often cause severe morbidity in survivors. NEC is an inflammatory mediated condition, but its pathophysiology remains poorly understood. There is increasing evidence that in LOS the causative organism most often translocates from the gut. No causative microorganism has been consistently associated with either LOS or NEC, but an aberrant gut microbiome development could play a pivotal role. A low bacterial diversity and a delay in anaerobic bacteria colonization may predispose preterm infants to disease development. Conversely, a predominance of Bifidobacterium species and breast milk feeding might help to prevent disease onset. With numerous studies reporting conflicting results, further research is needed to better understand the role of microorganisms and type of feeding in the health status of preterm infants.

KEYWORDS:

Gut; Microbiome; Necrotising enterocolitis; Preterm infant; Sepsis

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center