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Ann Pharmacother. 2019 Sep 3:1060028019873320. doi: 10.1177/1060028019873320. [Epub ahead of print]

Brexanolone (Zulresso): Finally, an FDA-Approved Treatment for Postpartum Depression.

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1 University of Florida Colleges of Pharmacy and Medicine, Gainesville, FL, USA.
2 Orlando VA Medical Center, Orlando, FL, USA.


Objective: To review the safety and efficacy of brexanolone for the treatment of moderate to severe postpartum depression (PPD). Data Sources: A literature search through PubMed was conducted (January 2012 to July 2019) using the keyword brexanolone for clinical trials published in the English language. Study Selection and Data Extraction: Articles were selected if they were related to the Food and Drug Administration (FDA) approval of brexanolone or provided novel clinical information regarding this drug entity. Data Synthesis: The findings of the review show that brexanolone administered via IV infusion is both an effective and a fairly safe option for the treatment of PPD. Relevance to Patient Care and Clinical Practice: There are several antidepressants currently used to treat PPD; however, this is the first with FDA approval for this indication. The rapid onset of action of brexanolone may offer a quicker relief of these symptoms and may possibly lead to improved quality of life for both the mother and the child. Conclusion and Relevance: The recent FDA approval of brexanolone may offer an effective treatment of moderate to severe PPD and has been shown to rapidly decrease depression symptoms.


Zulresso; brexanolone; depression; postpartum depression


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