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Clin Auton Res. 2020 Feb;30(1):13-18. doi: 10.1007/s10286-019-00608-w. Epub 2019 Sep 2.

Human papillomavirus (HPV) vaccine and autonomic disorders: a position statement from the American Autonomic Society.

Author information

1
Department of Neurology, NorthShore University Health System, Pritzker School of Medicine, University of Chicago, Chicago, IL, USA. ABarboi@northshore.org.
2
American Autonomic Society, 9500 Gilman Drive, BSB 5006, La Jolla, CA, 92093-0629, USA. ABarboi@northshore.org.
3
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard University, Boston, MA, USA.
4
Departments of Neurology, New York University, New York, NY, USA.
5
Department of Neurology, Mayo Clinic, Rochester, MN, USA.
6
Division of Clinical Pharmacology, Department of Medicine, Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
7
Departments of Medicine and Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA, USA.
8
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA.
9
Department of Neurology, Medical College of Wisconsin, Milwaukee, WI, USA.
10
Department of Neurology, Mayo Clinic, Jacksonville, FL, USA.
11
Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada.
12
Autonomic Medicine Section, National Institute of Neurological, Diseases and Stroke, National Institutes of Health, Bethesda, MD, USA.
13
Department of Anesthesia and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.
14
Departments of Physiology and Neurosciences, New York University, New York, NY, USA.
15
Cardiology Division, Wellstar Healthcare System, Atlanta, GA, USA.
16
Department of Neurology and Neurotherapeutics, UT Southwestern Medical Center, Dallas, TX, USA.
17
Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, AB, Canada.

Abstract

INTRODUCTION:

Human papillomavirus (HPV) vaccination has been anecdotally connected to the development of dysautonomia, chronic fatigue, complex regional pain syndrome and postural tachycardia syndrome.

OBJECTIVES:

To critically evaluate a potential connection between HPV vaccination and the above-noted conditions.

METHODS:

We reviewed the literature containing the biology of the virus, pathophysiology of infection, epidemiology of associated cancers, indications of HPV vaccination, safety surveillance data and published reports linking HPV vaccination to autonomic disorders.

RESULTS:

At this time, the American Autonomic Society finds that there are no data to support a causal relationship between HPV vaccination and CRPS, chronic fatigue, and postural tachycardia syndrome to other forms of dysautonomia.

CONCLUSION:

Certain conditions are prevalent in the same populations that are vaccinated with the HPV vaccine (peri-pubertal males and females). This association, however, is an insufficient proof of causality.

KEYWORDS:

Autonomic dysfunction; Consensus statement; HPV; Postural tachycardia syndrome; Vaccine

PMID:
31475305
DOI:
10.1007/s10286-019-00608-w

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