Send to

Choose Destination
Front Public Health. 2019 Aug 16;7:228. doi: 10.3389/fpubh.2019.00228. eCollection 2019.

Comparative Genomic Analysis of the 2016 Vibrio cholerae Outbreak in South Korea.

Author information

School of Biological Sciences, Seoul National University, Seoul, South Korea.
ChunLab Inc., Seoul, South Korea.
Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, South Korea.
Center for Laboratory Control of Infectious Diseases, Korea Centers for Disease Control, Cheongju-si, South Korea.
Centers for Disease Control and Prevention, Korea Centers for Disease Control, Cheongju-si, South Korea.
Food Microbiology Division, National Institute of Food and Drug Safety Evaluation, Chungcheongbuk-do, South Korea.


In August 2016, South Korea experienced a cholera outbreak that caused acute watery diarrhea in three patients. This outbreak was the first time in 15 years that an outbreak was not linked to an overseas source. To identify the cause and to study the epidemiological implications of this outbreak, we sequenced the whole genome of Vibrio cholerae isolates; three from each patient and one from a seawater sample. Herein we present comparative genomic data which reveals that the genome sequences of these four isolates are very similar. Interestingly, these isolates form a monophyletic clade with V. cholerae strains that caused an outbreak in the Philippines in 2011. The V. cholerae strains responsible for the Korean and Philippines outbreaks have almost identical genomes in which two unique genomic islands are shared, and they both lack SXT elements. Furthermore, we confirm that seawater is the likely source of this outbreak, which suggests the necessity for future routine surveillance of South Korea's seashore.


Vibrio cholerae; cholera; comparative genomics analysis; genome sequencing; molecular epidemiology

Supplemental Content

Full text links

Icon for Frontiers Media SA Icon for PubMed Central
Loading ...
Support Center