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Cell. 2019 Sep 5;178(6):1279-1281. doi: 10.1016/j.cell.2019.08.016. Epub 2019 Aug 29.

A Pungent and Painful Toxin.

Author information

1
The Solomon H. Snyder Department of Neuroscience, Department of Neurosurgery, Department of Dermatology, Center for Sensory Biology, Johns Hopkins University, School of Medicine, Baltimore, MD 21205. Electronic address: dgreen89@jhmi.edu.
2
The Solomon H. Snyder Department of Neuroscience, Department of Neurosurgery, Department of Dermatology, Center for Sensory Biology, Johns Hopkins University, School of Medicine, Baltimore, MD 21205; Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205. Electronic address: xdong2@jhmi.edu.

Abstract

In this issue of Cell, King et al. (2019) have discovered a cell penetrating peptide isolated from the venom of the Australian Black Rock scorpion that activates the TRPA1 receptor in a unique way to induce pain. Their findings offer new insights into how animals evolved venoms to target specific ion channel functions.

PMID:
31474364
DOI:
10.1016/j.cell.2019.08.016

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