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Int J Stem Cells. 2019 Nov 30;12(3):381-387. doi: 10.15283/ijsc19048.

Adult Stem Cells in Hibernation: Future Perspectives of Space Travel.

Chen YC1, Aui SP2, Lai YS2,3,4, Chang KT2,3,4.

Author information

1
Graduate Institute of Bioresources, National Pingtung University of Science and Technology, Neipu, Taiwan.
2
Department of Biological Science and Technology, National Pingtung University of Science and Technology, Neipu, Taiwan.
3
Flow Cytometry Center, Precision Instruments Center, National Pingtung University of Science and Technology, Neipu, Taiwan.
4
Research Center for Animal Biologics, National Pingtung University of Science and Technology, Neipu, Taiwan.

Abstract

Space traveling is imperative for mankind in the future. Expectedly, hibernation will become an option for space traveler to overcome the endless voyage. With regard to some of the studies pointed out that during hibernation, muscle will undergo atrophy and meantime neurogenesis will reduce, these obstacles were frequently related with stem cell regeneration. Thus, investigation on whether hibernation will lead to dysfunction of stem cell becomes an important issue. By going through four main systems in this article, such as, hematopoietic system, skeletal muscle system, central nervous system and orthopedic system, we are expecting that stem cells regeneration capacity will be affected by hibernation. To date, these researches are majorly the read-out from short term or seasonal hibernating mammals. Proposing and creating a simulated long-term hibernation animal model is turning essential for the further investigation on the effect of longer period of hibernation to human stem cells.

KEYWORDS:

Arousal; Hibernation; Stem cell; Torpor

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