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Stem Cell Res. 2019 Aug 21;40:101545. doi: 10.1016/j.scr.2019.101545. [Epub ahead of print]

Generation of two induced pluripotent stem cell lines from patients with unbalanced translocation (3;22).

Author information

1
Pediatric Research Institute, Qilu Children's Hospital of Shandong University, Jinan, Shandong 250022, China.
2
Rehabilitation Center, Qilu Children's Hospital of Shandong University, Jinan, Shangdong 250022, China.
3
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China.
4
Pediatric Research Institute, Qilu Children's Hospital of Shandong University, Jinan, Shandong 250022, China. Electronic address: gaizhongtao@sina.com.
5
Pediatric Research Institute, Qilu Children's Hospital of Shandong University, Jinan, Shandong 250022, China. Electronic address: y_liu99@sina.com.

Abstract

Here we describe the generation and characterization of the human induced pluripotent stem cell (iPSC) lines from urine-derived cells (UCs) from two patients with unbalanced chromosomal translocation t(3,22)(q28;q13.3). The iPSC lines retain the original chromosome abnormality, express pluripotency markers and bear differentiation potential.

PMID:
31472451
DOI:
10.1016/j.scr.2019.101545
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