Format

Send to

Choose Destination
Int J Cancer. 2019 Aug 31. doi: 10.1002/ijc.32659. [Epub ahead of print]

Associations between calcium and magnesium intake and the risk of incident gastric cancer, a prospective cohort analysis of the NIH-AARP Diet and Health Study.

Author information

1
Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University Medical Center, Nashville, Tennessee.
2
Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, Tennessee.
3
Division of Epidemiology, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.
4
Department of Health Policy, Vanderbilt University School of Medicine, Nashville, Tennessee.
5
Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.

Abstract

Gastric cancer remains a leading cause of cancer-related mortality. Identifying dietary and other modifiable disease determinants has important implications for risk attenuation in susceptible individuals. Our primary aim was to estimate the association between dietary and supplemental intakes of calcium and magnesium and the risk of incident gastric cancer. We conducted a prospective cohort analysis of the NIH-AARP Diet and Health Study. We used Cox proportional hazard modeling to estimate the association between calcium and magnesium intakes with risk of incident gastric adenocarcinoma (GA) overall and by anatomic location, noncardia (NCGA) and cardia (CGA). A total of 536,403 respondents (59% males, 41% females) were included for analysis, among whom 1,518 incident GAs (797 NCGA, 721 CGA) occurred. Increasing calcium intake was associated with lower risk of GA overall (p-trend = 0.05), driven primarily by the association with NCGA, where above median calcium intakes were associated with a 23% reduction in risk compared to the lowest quartile (p-trend = 0.05). This magnitude of NCGA risk reduction was greater among non-white races and Hispanics (HR 0.51, 95% CI: 0.24-1.07, p-trend = 0.04), current/former smokers (HR 0.58, 95% CI: 0.41-0.81), obese individuals (HR 0.54,95% CI: 0.31-0.96), and those with high NCGA risk scores (HR 0.50, 95% CI: 0.31-0.80). Among men only, increasing magnesium intake was associated with 22-27% reduced risk of NCGA (p-trend = 0.05), while for the cohort, dietary magnesium intake in the highest versus lowest quartile was associated with a 34% reduced risk of NCGA (HR 0.66, 95% CI: 0.48-0.90). These findings have important implications for risk factor modification and personalized prevention. Future investigations are needed not only to confirm our results, but to define mechanisms underlying these associations. This article is protected by copyright. All rights reserved.

KEYWORDS:

digestive system neoplasm; environment and public health; epidemiology; gastric neoplasm

PMID:
31472027
DOI:
10.1002/ijc.32659

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center