Format

Send to

Choose Destination
Gut. 2020 Feb;69(2):283-294. doi: 10.1136/gutjnl-2018-317431. Epub 2019 Aug 30.

Transfer of a healthy microbiota reduces amyloid and tau pathology in an Alzheimer's disease animal model.

Author information

1
Department of Life and Nanopharmaceutical Sciences and Department of Biology, Kyung Hee University, Dongdaemun-gu, Seoul, Republic of Korea.
2
Department of Microbiology and Molecular Biology, Chungnam National University, Daejeon, Republic of Korea.
3
Department of Biochemistry and Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea.
4
Interdisciplinary Graduate Program in Genetic Engineering, Seoul National University, Gwanak-gu, Seoul, Republic of Korea.
5
Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea.
6
Department of Life and Nanopharmaceutical Sciences and Department of Biology, Kyung Hee University, Dongdaemun-gu, Seoul, Republic of Korea baejw@khu.ac.kr inhee@snu.ac.kr.
7
Department of Biochemistry and Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea baejw@khu.ac.kr inhee@snu.ac.kr.
#
Contributed equally

Abstract

OBJECTIVE:

Cerebral amyloidosis and severe tauopathy in the brain are key pathological features of Alzheimer's disease (AD). Despite a strong influence of the intestinal microbiota on AD, the causal relationship between the gut microbiota and AD pathophysiology is still elusive.

DESIGN:

Using a recently developed AD-like pathology with amyloid and neurofibrillary tangles (ADLPAPT) transgenic mouse model of AD, which shows amyloid plaques, neurofibrillary tangles and reactive gliosis in their brains along with memory deficits, we examined the impact of the gut microbiota on AD pathogenesis.

RESULTS:

Composition of the gut microbiota in ADLPAPT mice differed from that of healthy wild-type (WT) mice. Besides, ADLPAPT mice showed a loss of epithelial barrier integrity and chronic intestinal and systemic inflammation. Both frequent transfer and transplantation of the faecal microbiota from WT mice into ADLPAPT mice ameliorated the formation of amyloid β plaques and neurofibrillary tangles, glial reactivity and cognitive impairment. Additionally, the faecal microbiota transfer reversed abnormalities in the colonic expression of genes related to intestinal macrophage activity and the circulating blood inflammatory monocytes in the ADLPAPT recipient mice.

CONCLUSION:

These results indicate that microbiota-mediated intestinal and systemic immune aberrations contribute to the pathogenesis of AD in ADLPAPT mice, providing new insights into the relationship between the gut (colonic gene expression, gut permeability), blood (blood immune cell population) and brain (pathology) axis and AD (memory deficits). Thus, restoring gut microbial homeostasis may have beneficial effects on AD treatment.

KEYWORDS:

Alzheimer’s disease; beta-amyloid; fecal microbiota transfer; gut microbiota; hyperphosphorylated tau

PMID:
31471351
DOI:
10.1136/gutjnl-2018-317431

Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center