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Epidemiology. 2019 Nov;30(6):918-926. doi: 10.1097/EDE.0000000000001092.

Hospitalizations Associated with Respiratory Syncytial Virus and Influenza in Children, Including Children Diagnosed with Asthma.

Author information

1
From the Department of Epidemiology, Center for Communicable Disease Dynamics, Harvard TH Chan School of Public Health, Boston, MA.
2
Vaccines Division, Merck & Co., Inc., Kenilworth, NJ.
3
Influenza Division, National Center for Immunization and Respiratory Diseases, US CDC, Atlanta, GA.
4
Yale School of Medicine, New Haven, CT.
5
Division of International Epidemiology and Population Studies, Agency for Healthcare Research and Quality, United States Department of Health and Human Services, Rockville, MD.
6
Division of International Epidemiology and Population Studies, Fogarty International Center, National Institutes of Health, Bethesda, MD.
7
Department of Immunology and Infectious Diseases, Harvard TH Chan School of Public Health, Boston, MA.

Abstract

BACKGROUND:

There is uncertainty about the burden of hospitalization associated with respiratory syncytial virus (RSV) and influenza in children, including those with underlying medical conditions.

METHODS:

We applied previously developed methodology to Health Care Cost and Utilization Project hospitalization data and additional data related to asthma diagnosis/previous history in hospitalized children to estimate RSV and influenza-associated hospitalization rates in different subpopulations of US children between 2003 and 2010.

RESULTS:

The estimated average annual rates (per 100,000 children) of RSV-associated hospitalization with a respiratory cause (ICD-9 codes 460-519) present anywhere in the discharge diagnosis were 2,381 (95% CI(2252,2515)) in children <1 year of age; 710.6 (609.1, 809.2) (1 y old); 395 (327.7, 462.4) (2 y old); 211.3 (154.6, 266.8) (3 y old); 111.1 (62.4, 160.1) (4 y old); 72.3 (29.3, 116.4) (5-6 y of age); 35.6 (9.9,62.2) (7-11 y of age); and 39 (17.5, 60.6) (12-17 y of age). The corresponding rates of influenza-associated hospitalization were lower, ranging from 181 (142.5, 220.3) in <1 year old to 17.9 (11.7, 24.2) in 12-17 years of age. The relative risks for RSV-related hospitalization associated with a prior diagnosis of asthma in age groups <5 y ranged between 3.1 (2.1, 4.7) (<1 y old) and 6.7 (4.2, 11.8) (2 y old; the corresponding risks for influenza-related hospitalization ranged from 2.8 (2.1, 4) (<1y old) to 4.9 (3.8, 6.4) (3 y old).

CONCLUSION:

RSV-associated hospitalization rates in young children are high and decline rapidly with age. There are additional risks for both RSV and influenza hospitalization associated with a prior diagnosis of asthma, with the rates of RSV-related hospitalization in the youngest children diagnosed with asthma being particularly high.

PMID:
31469696
PMCID:
PMC6768705
[Available on 2020-11-01]
DOI:
10.1097/EDE.0000000000001092

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