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Int J Geriatr Psychiatry. 2019 Aug 30. doi: 10.1002/gps.5205. [Epub ahead of print]

Prevalence and correlates of dementia and mild cognitive impairment classified with different versions of the modified Telephone Interview for Cognitive Status (TICS-m).

Author information

1
Turku PET Centre, University of Turku, Turku, Finland.
2
Drug Research Doctoral Program, University of Turku, Turku, Finland.
3
Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
4
Division of Clinical Neurosciences, Turku University Hospital, Turku, Finland.
5
Department of Public Health, University of Helsinki, Helsinki, Finland.

Abstract

OBJECTIVES:

The modified Telephone Interview for Cognitive Status (TICS-m) is an efficient and cost-effective screening instrument of dementia, but there is less support for its utility in the detection of mild cognitive impairment (MCI). We undertook a comprehensive evaluation of the utility of different TICS-m versions with or without an education-adjusted scoring method to classify dementia and MCI in a large population-based sample.

METHODS:

Cross-sectional assessment of cognition (TICS-m), depressive symptoms (CES-D), and apolipoprotein E (APOE) ε4 status was performed on 1772 older adults (aged 71-78 y, education 5-16 y, 50% female) from the population-based older Finnish Twin Cohort. TICS-m classification methods with and without education adjustment were used to classify individuals with normal cognition, MCI, or dementia.

RESULTS:

The prevalence of dementia and MCI varied between education-adjusted (dementia = 3.7%, MCI = 9.3%) and unadjusted classifications (dementia = 8.5%-11%, MCI = 22.3%-41.3%). APOE ε4 status was associated with dementia irrespective of education adjustment, but with MCI only when education adjustment was used. Regardless of the version, poorer continuous TICS-m scores were associated with higher age, lower education, more depressive symptoms, male sex, and being an APOE ε4 carrier.

CONCLUSIONS:

We showed that demographic factors, APOE ε4 status, and depressive symptoms were similarly related to continuous TICS-m scores and dementia classifications with different versions. However, education-adjusted classification resulted in a lower prevalence of dementia and MCI and in a higher proportion of APOE ε4 allele carriers among those identified as having MCI. Our results support the use of education-adjusted classification especially in the context of MCI.

KEYWORDS:

APOE genotype; cognition; cognitive status; dementia; depressive symptoms; education; memory and learning tests; mild cognitive impairment; sex differences; telephone screening

PMID:
31469194
DOI:
10.1002/gps.5205

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