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Pediatr Clin North Am. 2019 Oct;66(5):913-923. doi: 10.1016/j.pcl.2019.06.007.

Newborn Screening for Severe Combined Immunodeficiency.

Author information

1
Department of Pediatrics, Children's Hospital of Michigan, 3901 Beaubien Street, Detroit, MI 48201, USA.
2
Department of Allergy and Immunology, Children's Hospital of Michigan, 3901 Beaubien Street, Detroit, MI 48201, USA. Electronic address: Ae8701@wayne.edu.

Abstract

The T-cell receptor excision circle (TREC) assay is an effective screening tool for severe combined immunodeficiency (SCID). The TREC assay was designed to detect typical SCID and leaky SCID, but any condition causing low naïve T-cell counts will also be detected. Newborn screening for SCID using the TREC assay has proven itself to be highly sensitive and cost-efficient. This review covers the history of SCID newborn screening, elaborates on the SCID subtypes and TREC assay limitations, and discusses diagnostic and management considerations for infants with a positive screen.

KEYWORDS:

Newborn screening (NBS); Severe combined immunodeficiency (SCID); T-cell lymphopenia; T-cell receptor excision circle (tREC)

PMID:
31466681
DOI:
10.1016/j.pcl.2019.06.007

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