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Scand J Public Health. 2019 Aug 29:1403494819869816. doi: 10.1177/1403494819869816. [Epub ahead of print]

CVD risk factors and surrogate markers - Urban-rural differences.

Author information

1
1 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland.
2
2 Heart Centre, Turku University Hospital and University of Turku, Finland.
3
3 Paavo Nurmi Centre, Department of Physical Activity and Health, University of Turku, Finland.
4
4 Menzies Research Institute Tasmania, University of Tasmania, Australia.
5
5 Department of Paediatrics, University of Tampere and Tampere University Hospital, Finland.
6
6 Department of Clinical Physiology, University of Tampere School of Medicine and Tampere University Hospital, Finland.
7
7 Department of Clinical Physiology and Nuclear Medicine, University of Eastern Finland and Kuopio University Hospital, Finland.
8
8 Vaasa Central Hospital, Finland.
9
9 Department of Paediatrics, University of Oulu, Finland.
10
10 Fimlab Laboratories and Finnish Cardiovascular Research Centre-Tampere, University of Tampere, Finland.
11
11 Department of Pediatric Cardiology, Hospital for Children and Adolescents, University of Helsinki, Finland.
12
12 Department of Medicine, University of Turku, Finland.
13
13 Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Finland.
14
14 Murdoch Children's Research Institute, Melbourne, Australia.

Abstract

Aims: Disparity in cardiovascular disease (CVD) mortality and risk factor levels between urban and rural regions has been confirmed worldwide. The aim of this study was to examine how living in different community types (urban-rural) in childhood and adulthood are related to cardiovascular risk factors and surrogate markers of CVD such as carotid intima-media thickness (IMT) and left ventricular mass (LVM). Methods: The study population comprised 2903 participants (54.1% female, mean age 10.5 years in 1980) of the Cardiovascular Risk in Young Finns Study who had been clinically examined in 1980 (age 3-18 years) and had participated in at least one adult follow-up (2001-2011). Results: In adulthood, urban residents had lower systolic blood pressure (-1 mmHg), LDL-cholesterol (-0.05 mmol/l), lower body mass index (-1.0 kg/m2) and glycosylated haemoglobin levels (-0.05 mmol/mol), and lower prevalence of metabolic syndrome (19.9 v. 23.7%) than their rural counterparts. In addition, participants continuously living in urban areas had significantly lower IMT (-0.01 mm), LVM (1.59 g/m2.7) and pulse wave velocity (-0.22 m/s) and higher carotid artery compliance (0.07%/10 mmHg) compared to persistently rural residents. The differences in surrogate markers of CVD were only partially attenuated when adjusted for cardiovascular risk factors. Conclusions: Participants living in urban communities had a more favourable cardiovascular risk factor profile than rural residents. Furthermore, participants continuously living in urban areas had less subclinical markers related to CVD compared with participants living in rural areas. Urban-rural differences in cardiovascular health might provide important opportunities for optimizing prevention by targeting areas of highest need.

KEYWORDS:

Atherosclerosis; arterial stiffness; left ventricular mass; risk factors; rural; urban

PMID:
31464561
DOI:
10.1177/1403494819869816

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