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Lung India. 2019 Sep-Oct;36(5):417-421. doi: 10.4103/lungindia.lungindia_27_19.

Quadriceps strength in patients with chronic obstructive pulmonary disease.

Author information

1
Department of Physiology, B.J. Government Medical College; Department of Health and Biomedical Sciences, Symbiosis International (Deemed) University, Pune, Maharashtra, India.
2
Student of MTech Mechatronics, College of Engineering Pune, Pune, Maharashtra, India.
3
Department of Health and Biomedical Sciences, Symbiosis International (Deemed) University, Pune, Maharashtra, India.
4
Department of Physiology, B.J. Government Medical College, Pune, Maharashtra, India.

Abstract

Background:

Skeletal muscle dysfunction is well known in chronic obstructive pulmonary disease (COPD). The muscle strength is altered in various muscles variedly. Lower-limb muscle strength is very important for walking distance. Reduced lower-limb strength can affect the physical quality of life.

Objectives:

The aim of the study was to assess and compare the quadriceps strength in COPD patients and age-matched healthy controls and to study the correlation between lung function parameters and the quadriceps strength in patients with COPD.

Methodology:

Thirty nonsmoker male patients; thirty nonsmoker female patients with COPD; and sixty age-, BMI-, and gender-matched healthy controls were studied. Quadriceps muscle strength was measured using a quadriceps dynamometer. Forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), FEF 25-75, and peak expiratory flow rate were measured using Helios 702 Spirometer. The quadriceps muscle strength between the two groups was compared using the unpaired Student's t-test. Correlations between FVC and FEV1with muscle strength were analyzed using the Pearson's coefficient.

Results:

The mean unilateral and bilateral quadriceps strength in both male and female COPD patients was significantly lesser than the healthy controls (P < 0.05). There was a significant positive correlation between muscle strength and FVC and muscle strength and FEV1in patients with COPD.

Conclusion:

The study shows that there is quadriceps weakness in COPD patients, and pulmonary functions have a direct impact on skeletal muscle strength. Identifying those patients who have reduced strength will allow early interventions targeted at improving the quality of life of the patient.

KEYWORDS:

Chronic obstructive pulmonary disease; forced vital capacity; muscle strength; quadriceps

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