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Nature. 2019 Sep;573(7772):126-129. doi: 10.1038/s41586-019-1520-9. Epub 2019 Aug 28.

Natural selection on the Arabidopsis thaliana genome in present and future climates.

Author information

1
Department of Molecular Biology, Max Planck Institute for Developmental Biology, Tübingen, Germany.
2
Globe Institute, University of Copenhagen, Copenhagen, Denmark.
3
Department of Plant Biology, Carnegie Institution for Science, Stanford, CA, USA.
4
Research Group of Ancient Genomics and Evolution, Max Planck Institute for Developmental Biology, Tübingen, Germany.
5
Centre for Life's Origins and Evolution, Department of Genetics, Evolution, and Environment, University College London, London, UK.
6
Institute of Evolution and Ecology, University of Tübingen, Tübingen, Germany.
7
Department of Integrative Biology, University of California Berkeley, Berkeley, CA, USA.
8
Department of Statistics, University of California Berkeley, Berkeley, CA, USA.
9
Department of Molecular Biology, Max Planck Institute for Developmental Biology, Tübingen, Germany. weigel@weigelworld.org.

Abstract

Through the lens of evolution, climate change is an agent of natural selection that forces populations to change and adapt, or face extinction. However, current assessments of the risk of biodiversity associated with climate change1 do not typically take into account how natural selection influences populations differently depending on their genetic makeup2. Here we make use of the extensive genome information that is available for Arabidopsis thaliana and measure how manipulation of the amount of rainfall affected the fitness of 517 natural Arabidopsis lines that were grown in Spain and Germany. This allowed us to directly infer selection along the genome3. Natural selection was particularly strong in the hot-dry location in Spain, where 63% of lines were killed and where natural selection substantially changed the frequency of approximately 5% of all genome-wide variants. A significant portion of this climate-driven natural selection of variants was predictable from signatures of local adaptation (R2 = 29-52%), as genetic variants that were found in geographical areas with climates more similar to the experimental sites were positively selected. Field-validated predictions across the species range indicated that Mediterranean and western Siberian populations-at the edges of the environmental limits of this species-currently experience the strongest climate-driven selection. With more frequent droughts and rising temperatures in Europe4, we forecast an increase in directional natural selection moving northwards from the southern end of Europe, putting many native A. thaliana populations at evolutionary risk.

PMID:
31462776
DOI:
10.1038/s41586-019-1520-9

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