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J Clin Microbiol. 2019 Aug 28. pii: JCM.00985-19. doi: 10.1128/JCM.00985-19. [Epub ahead of print]

Comparing QuantiFERON-TB Gold Plus with other tests to diagnose Mycobacterium tuberculosis infection.

Author information

1
Division of Tuberculosis Elimination, Centers for Disease Control and Prevention, Atlanta, GA, USA kyx2@cdc.gov.
2
Northrop Grumman, Atlanta, GA, USA.
3
Division of Tuberculosis Elimination, Centers for Disease Control and Prevention, Atlanta, GA, USA.
4
Denver Health and Hospital Authority, Denver, CO, USA.
5
Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
6
Department of Pathology and Genomic Medicine, Houston Methodist Research Institute, Houston, TX, USA.

Abstract

The fourth generation QuantiFERON test for tuberculosis infection, QuantiFERON-TB Gold Plus (QFT-Plus) has replaced the earlier version, QuantiFERON-TB Gold In-Tube (QFT-GIT). A clinical need exists for information about agreement between QFT-Plus and other tests.We conducted this study to assess agreement of test results for QFT-Plus with those of QuantiFERON-TB Gold In-Tube (QFT-GIT), T-SPOT.TB (T-SPOT) and the tuberculin skin test (TST).Persons at high risk of LTBI and/or progression to TB disease were enrolled at the 10 sites of the Tuberculosis Epidemiologic Studies Consortium from October 2016 through May 2017; each participant received all four tests. Cohen's kappa (κ) and Wilcoxon signed rank test compared qualitative and quantitative results of QFT-Plus with the other tests.Test results for 506 participants showed 94% agreement between QFT-Plus and QFT-GIT, with 19% positive and 75% negative results. When the tests disagreed, it was most often in the direction of QFT-GIT negative/QFT-Plus positive. QFT-Plus had similar concordance as QFT-GIT with TST (77% and 77%) and T-SPOT (92% and 91%), respectively.Conclusions: The study showed high agreement between QFT-GIT and QFT-Plus in a direct comparison. Both tests had similar agreement with TST and T-SPOT.

PMID:
31462550
DOI:
10.1128/JCM.00985-19

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