The article reports data concerning 260 patients with epilepsy who were treated by different variants of operations on the open brain. The duration of the catamnesis ranged from 3 to 17 years. It is shown that the results of the treatment are determined by some initial data, in particular, the features of the psychopathological and neuropsychological disorders and their degree. Criteria of the selection of patients with epilepsy and mental disorders for surgical management are formulated.