Format

Send to

Choose Destination
Int J Mol Sci. 2019 Aug 27;20(17). pii: E4192. doi: 10.3390/ijms20174192.

Liver X Receptors and Their Implications in the Physiology and Pathology of the Peripheral Nervous System.

Author information

1
Faculty of Basic and Biomedical Sciences, Paris Descartes University, INSERM UMRS 1124, 75006 Paris, France.
2
Faculty of Basic and Biomedical Sciences, Paris Descartes University, INSERM UMRS 1124, 75006 Paris, France. julien.grenier@parisdescartes.fr.

Abstract

Recent research in the last decade has sought to explore the role and therapeutic potential of Liver X Receptors (LXRs) in the physiology and pathologies of the Peripheral Nervous System. LXRs have been shown to be important in maintaining the redox homeostasis in peripheral nerves for proper myelination, and they regulate ER stress in sensory neurons. Furthermore, LXR stimulation has a positive impact on abrogating the effects of diabetic peripheral neuropathy and obesity-induced allodynia in the Peripheral Nervous System (PNS). This review details these findings and addresses certain important questions that are yet to be answered. The potential roles of LXRs in different cells of the PNS are speculated based on existing knowledge. The review also aims to provide important perspectives for further research in elucidating the role of LXRs and assessing the potential of LXR based therapies to combat pathologies of the Peripheral Nervous System.

KEYWORDS:

LXR; cholesterol; myelin; oxysterol; peripheral nervous system; schwann cell

PMID:
31461876
DOI:
10.3390/ijms20174192
Free full text

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI)
Loading ...
Support Center