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Mol Immunol. 1988 Oct;25(10):991-5.

Hybridoma fusion cell lines contain an aberrant kappa transcript.

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Department of Medicine, Stanford University School of Medicine, CA 94305.


The V region sequence of a non-productive kappa transcript from two myeloma fusion partners has been determined. This transcript has an aberrant VJ recombination site resulting in a translation stop site at position 105. It is variably expressed in hybridomas made from all fusion partners derived from the original MOPC-21 tumor. The amount of this transcript may greatly exceed levels of the productive light chain mRNA.

[Indexed for MEDLINE]

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