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ACS Omega. 2018 Aug 15;3(8):9126-9145. doi: 10.1021/acsomega.8b01071. eCollection 2018 Aug 31.

Multifunctional Carbon-Based Nanomaterials: Applications in Biomolecular Imaging and Therapy.

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Department of Medical Imaging, Second Hospital of Tianjin Medical University, Tianjin 300211, P. R. China.
Department of Radiology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, P. R. China.
Institut National de la Recherche Scientifique-Énergie Matériaux et Télécommunications, Varennes, Quebec J3X 1S2, Canada.
School of Pharmaceutical Science, Nanjing Tech University, Nanjing 211816, P. R. China.


Molecular imaging has been widely used not only as an important detection technology in the field of medical imaging for cancer diagnosis but also as a theranostic approach for cancer in recent years. Multifunctional carbon-based nanomaterials (MCBNs), characterized by unparalleled optical, electronic, and thermal properties, have attracted increasing interest and demonstrably hold the greatest promise in biomolecular imaging and therapy. As such, it should come as no surprise that MCBNs have already revealed a great deal of potential applications in biomedical areas, such as bioimaging, drug delivery, and tumor therapy. Carbon nanomaterials can be categorized as graphene, single-walled carbon nanotubes, mesoporous carbon, nanodiamonds, fullerenes, or carbon dots on the basis of their morphologies. In this article, reports of the use of MCBNs in various chemical conjugation/functionalization strategies, focusing on their applications in cancer molecular imaging and imaging-guided therapy, will be comprehensively summarized. MCBNs show the possibility to serve as optimal candidates for precise cancer biotheranostics.

Conflict of interest statement

The authors declare no competing financial interest.

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