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Eur J Clin Invest. 2019 Oct;49(10):e13166. doi: 10.1111/eci.13166. Epub 2019 Sep 19.

Prevalence and characteristics of renal artery fibromuscular dysplasia in hypertensive women below 50 years old.

Author information

1
Division of Cardiology, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium.
2
Department of Medical Sciences, Internal Medicine and Hypertension Division, AOU Città della Salute e della Scienza, University of Turin, Turin, Italy.
3
Department of Nephrology, Grand Hôpital De Charleroi, Gilly, Belgium.
4
Division of Radiology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.
5
Department of Internal Medicine, ESH Hypertension Excellence Centre, Hôpital Avicenne, Centre Hospitalier Universitaire, Bobigny, France.
6
Sorbonne Université, Université Paris 13, Sorbonne Paris Cité, INSERM, UMR_S 1142, LIMICS, IRSAN, Paris, France.
7
Pole of Cardiovascular Research, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium.

Abstract

BACKGROUND:

Renal fibromuscular dysplasia (FMD) is typically diagnosed in young hypertensive women. The 2014 European FMD Consensus recommended screening in all hypertensive women <30 yo. However, the prevalence of renal FMD in young/middle-aged hypertensive women remains unclear. The aim of this work was to assess the prevalence and characteristics of renal FMD in hypertensive women ≤50 yo.

METHODS:

We retrospectively included all consecutive women aged ≤50 years referred to our Hypertension Unit from 2014 to 2017 and collected standardized information on patient characteristics and screening modalities.

RESULTS:

Of 1083 incident hypertensive patients, 157 patients fitted with inclusion criteria. The prevalence of renal FMD varied between 3.2% in the whole sample and 7.5% in patients explored by CTA and/or MRA (n = 67). In the subgroup of patients ≤30 yo (n = 32), the corresponding figures were 3.1% and 5.6%. The yearly prevalence of FMD tended to increase over time, in parallel with increased use of CTA/MRA as a first-line imaging modality. Out of 5 patients with renal FMD, 2 were revascularized and 1 had extra-renal FMD.

CONCLUSIONS:

The prevalence of renal FMD in young/middle-aged hypertensive women is probably one order of magnitude higher than previously assumed, in the range of 3%-8%, depending on imaging modalities. While the diagnosis of FMD does not influence short-term management in all patients, it may allow close monitoring and prevention of complications of the disease over time. This analysis provides the rationale for a prospective, multicentre study aiming at determining the cost-effectiveness of systematic screening for renal FMD.

KEYWORDS:

computed tomographic angiography; fibromuscular dysplasia; hypertension; renal artery stenosis; renal duplex

PMID:
31454065
DOI:
10.1111/eci.13166

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